In 1976, nearly 80 years after Bram Stoker published Dracula, Anne Rice's bestselling first novel, Interview with the Vampire, reinvented the vampire myth. Rice recast the undead as a secret society of decadent aesthetes, alternately entranced by the world's beauty and haunted by spiritual despair. Set largely in the author's home city of New Orleans, the book created a fantasy underworld rich and compelling enough to sustain its writer and readers through nine sequels, known collectively as The Vampire Chronicles.

Rice wrote Interview with the Vampire, she said later, "without ever realizing I was writing about loss. I was writing about my daughter's loss [Rice's daughter died in 1972]. And I was writing about my loss of Catholic faith long before that, because I had lost my faith in the year 1960, when I first went to college."

After her first book, Rice continued to write about loss -- and about vampires, witches and demons -- for more than 25 years. She also wrote, under the pen name A.N. Roquelaure, the Beauty series, an erotic retelling of the story of Sleeping Beauty; writing as Anne Rampling, she published two other novels, Exit to Eden and Belinda.

But it is as the queen of gothic fiction that Anne Rice's fans know her best. Her fans are passionate about her, and she returns the sentiment, e-mailing tirelessly with them and occasionally posting on their blogs. She also adores communing with them in person on book tours: "They give me personal, priceless and unforgettable feedback and verification of what I have achieved for them in my books," she once explained in a Salon interview.

After Blood Canticle was released in 1993, her readers, accustomed to an output of one book a year, kept asking her what was coming next. "And I've told them, 'You may not want what I'm doing next'," she said in a Newsweek interview.

They were in for a surprise. In 1998, Rice had returned to the Roman Catholic Church, and in 2005 she published Christ the Lord: Out of Egypt, a novel about the childhood of Jesus, narrated by himself.

"It's the most startling public turnaround since Bob Dylan's Slow Train Coming announced that he'd been born again," wrote David Gates in Newsweek.

But as Rice sees it, Christ the Lord represents the fulfillment of a longing that has been in her books, and in her soul, all along.

"This subject is in no way a departure from that of my previous works; no one who knows my work could possibly think so," she said in a Q&A on her publisher's Web site. "The whole theme of Interview with the Vampire was Louis's quest for meaning in a godless world. He searched to find the oldest existing `immortal' simply to ask `What is the meaning of what we are?' I was always compelled to seek the `big answers.'"

Christ the Lord received mixed reviews, but many critics were as impressed with the book's style as its ambitious subject matter. "Rice's book is a triumph of tone -- her prose lean, lyrical, vivid -- and character," noted Kirkus Reviews. Janet Maslin wrote in The New York Times Book Review: "Even in biblical times and in the Holy Land, Rice retains her obsessions with ritual and purification, with lavish detail and gaudy decor. But she writes this book in a simpler, leaner style, giving it the slow but inexorable rhythm of an incantation. The restraint and prayerful beauty of Christ the Lord is apt to surprise her usual readers and attract new ones."

Some of those usual readers, of course, are now wondering whether she will write any more vampire novels. Will the vampire Lestat ever return?

Anne's response, from her publisher's Web site: "I can't see myself doing that. My vampires were metaphors for the outsiders, the lost, the wanderers in the darkness who remembered the warmth of God's light but couldn't find it. My wish to explore that is gone now. I want to meet a much bigger challenge."