Born in Exeter, New Hampshire in 1964, Brown attended Phillips Exeter Academy (where his father taught), and graduated from Amherst with a double major in Spanish and English. After college he supported himself through teaching and enjoyed moderate success as a musician and songwriter.

Brown credits Sidney Sheldon with jump-starting his literary career. Up until 1994, his reading tastes were focused sharply on the classics. Then, on vacation in Tahiti, he stumbled on a paperback copy of Sheldon's novel The Doomsday Conspiracy. By the time he finished the book, he had decided he could do as well. There and then, he determined to try his hand at writing. His first attempt was a pseudonymously written self-help book for women co-written with his future wife Blythe Newlon. Then, in 1998, he published his first novel, Digital Fortress -- followed in swift succession by Angels and Demons and Deception Point. None the three achieved commercial success.

Then, in 2003, Brown hit the jackpot with his fourth novel, a compulsively readable thriller about a Harvard symbologist named Robert Langdon who stumbles on an ancient conspiracy in the wake of a shocking murder in the Louvre. Combining elements from art, science, and religion, The Da Vinci Code became the biggest bestseller in publishing history, inspiring a big-budget movie adaptation and fueling interest in the author's back list. In 2009, Brown continued Robert Langdon's esoteric adventures with The Lost Symbol, a tale of intrigue that, like its predecessors, takes readers on a wild ride into the sinister mysteries of the past.