Antioxidant and Redox Regulation of Genes

by Chandan K. Sen (Editor), Lester Packer (Editor), Patrick A. Baeuerle (Editor)

Overview

This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized.

• Reactive species as intracellular messengers
• Redox regulation of cellular responses
• Clinical implications of redox signaling and antioxidant therapy

Product Details

ISBN-13:	9780080527291
Publisher:	Elsevier Science
Publication date:	11/08/1999
Sold by:	Barnes & Noble
Format:	eBook
Pages:	562
File size:	8 MB

About the Author

Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine&Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants&Redox Signaling(www.liebertpub.com/ars) with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.
Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California.

Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l’Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California.

He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology:

Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the “Antioxidant Network” regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell’s redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

Table of Contents

Reactive Species as Intracellular Messengers:
L.-O. Klotz, K. Briviba, and H. Sies, Signalling by Singlet Oxygen in Biological Systems.
D.R. Crawford, T. Suzuki, and K.J.A. Davies, Oxidant-modulated Gene Expression.
H.H. Hassanain and P.J. Goldschmidt-Clermont, RAC, Superoxide, and Signal Transduction.
S.K. Koliwad, A.K. Brzezinska, and S.J. Elliott, Redox Regulation of Ion Channels.
J. Giron-Calle and H.J. Forman, Cell Ca²⁺ in Signal Transduction: Modulation in Oxidative Stress.
G.L. Schieven, Introduction of Protein Tyrosine Phosphorylation by Oxidative Stress and its Implications.
A.A. Deora and H.M. Lander, Regulation of Signal Transduction and Gene Expression by Reactive Nitrogen Species.
Redox Sensitive Molecular Processes and Cellular Responses:
P.A. Baeuerle, Reactive Oxygen Species as Costimulatory Signals of Cytokine-Induced NFkappaB Activation Pathways.
T. Okamoto, T. Tetsuka, and T. Kawabe, Redox Regulation of Nuclear Factor kappa B.
C.K. Sen, Oxidants and Antioxidants in Aptosis: Role of Bcl-2.
V. Goossens, K. De Vos, D. Vercammen, M. Steemans, K. Vancompernolle, W. Fiers, P. Vandenabeele, and J. Grooten, Role of Reactive Oxygen Species in TNF Toxicity.
S. Roy, C.K. Sen, A. Gozin, V. Andrieu, and C. Pasquier, Redox Regulation of Cell Adhesion Processes.
H. Masutani, M. Ueno, S. Ueda, and J. Yodoi, Role of Thioredoxin and Redox Regulation in Oxidative Stress Response and Signalling.
A.H. Schönthal, S. Mueller, and E. Cadenas, Redox Regulation of p21, Role of Reactive Oxygen and Nitrogen Species in Cell Cycle Progression.
Clinical Implications of Redox Signaling and Antioxidant Therapy:
H. Viita and S. Ylä-Hertuala, Effect of Lipoxygenases on Gene Expression in Mammalian Cells.
A. Azzi, Tocopherol in the Pathogenesis of Atherosclerosis: One Molecule, Several Functions.
D.-Y. Jin and K.-T. Jeang, Peroxiredoxins in Cell Signaling and HIV Infection.
J.S. Bertram, T. King, L. Fukishima, and F. Khachik, Enhanced Activity of an Oxidation Product of Lycopene Found in Tomato Products and Human Serum Relevant to Cancer Prevention.
C. Bladier, J.B. de Haan, and I. Kola, Antioxidant Genes and Reactive Oxygen Species in Down's Syndrome.
B.S. Kristal and B.P. Yu, Oxidant-mediated Repression of mtDNA Transcription.
Y. Kajimoto, Y. Yamasaki, T. Matsuoka, H. Kaneto, and M. Hori, Suppression of the Insulin Gene Promoter Activity by Oxidative Stress.
N. Maulik and D.K. Das, Redox Regulation of Ischemic Adaptation.
W.C. Orr and R.S. Sohal, Oxidative Stress as a Governing Factor in Physiological Aging.
W. Dröge, V. Hack, R. Breitkreutz, E. Holm, S. Holm, and R. Kinscherf, Antioxidants in Senescence and Wasting.
Subject Index.

Editorial Reviews

Reviewer: Michael B. Lilly, MD (Loma Linda University)
Description: This is a compilation of review articles on various aspects of antioxidant and redox regulation of gene expression and signal transduction pathways.
Purpose: The explosion of information on the molecular effects of antioxidants and reactive oxygen species in cell biology has created a need for just this sort of volume. The editors have sought to present an "up-to-the-minute snapshot" of the field. In this compendium they admirably distill thousands of articles into a cohesive summary that will serve to update established workers in the field, as well as to introduce new researchers to the current thinking about redox regulation.
Audience: The audience is more likely to be researchers who have significant knowledge of cellular and molecular biology than less experienced workers. A chapter or two introducing the basic technology and reagents would have been helpful in broadening the usefulness of the book.
Features: The book consists of 24 chapters authored by different experts in the field. These are grouped into three sections in which they cover the role of reactive oxygen species (RCS) as intracellular messengers, redox regulation of cellular processes, and clinical implications of antioxidants and redox signaling. These are logical groupings and serve to highlight the common themes of the various chapters. Most chapters are quite good, and contributors provide comprehensive summaries. There are a few, however, in which primary research data is presented — and these are less helpful, though they certainly stimulate thought. While many of the chapter contributors deal with similar themes, such as signaling through the transcription factor NF-kappaB, there is remarkably little overlap and repetition of facts. Careful editing is apparent from the references in some chapters to accompanying chapters. These directions clearly help limit redundancy and are a helpful feature. Illustrations are generally plentiful and pertinent. A small number are repeated as color plates, though some are not of the highest quality. While much of the data the contributors discuss are about signal transduction pathways, other areas are less well covered. Somewhat surprising is the brief treatment of antioxidant response elements and their role in regulation of genes — particularly in view of the title. Similarly, the vast field of phytochemicals with antioxidant and anti-inflammatory properties gets brief treatment, and contributors focus only on one class of agents, the lyopenes.
Assessment: This is a worthwhile addition to the literature. There really is no competition at present, and future updates will likely be eagerly received.

Doody's Review Service