Table of Contents
Dedication iii
Acknowledgements iv
How to Use this Book v
1 General Properties of Microorganisms 1
I The Microbial World 1
II Host-Parasite Relationship 3
III Sterilization and Disinfection 4
Review Test 5
2 Bacteria 7
I Bacterial Structure 7
II Bacterial Growth and Replication 13
III Bacterial Viruses 17
IV Genetics 22
V Bacterial Pathogenesis 30
VI Host Defenses to Bacteria 32
VII Antimicrobial Chemotherapy 32
Review Test 37
3 Important Bacterial Genera 41
I Clinical Laboratory Identification 41
II Introduction to Major Bacterial Genera 49
III Gram-Positive Bacteria 50
IV Gram-Negative Bacteria 53
V Poorly Gram-Staining Bacteria 56
Review Test 60
4 Bacterial Diseases 65
I Major Recurring Species 65
II Eye Infections 69
III Dental Disease 70
IV Ear and Sinus Infections 71
V Bacterial Pharyngitis 71
VI Infections of the Respiratory System 72
VII Pneumonia/Pneumonitis 74
VIII Nervous System Infections: Meningitis 80
IX Nervous System Infections: Nonmeningitis Conditions 83
X Cardiovascular Infections: Vasculitis 83
XI Cardiovascular Infections: Endocarditis 83
XII Cardiovascular: Myocarditis 85
XIII Gastrointestinal Infections 85
XIV Urinary Tract Infections 91
XV Skin, Mucosal, Soft Tissue, and Bone Infections 92
XVI Sexually Transmitted Infections (STIs) 95
XVII Pregnancy, Congenital, and Perinatal Infections 98
XVIII Arthropod-Borne and Zoonotic Diseases 98
XIX Bacterial Vaccines 102
Review Test 107
5 Viruses 112
I Nature of Human Viruses 112
II Viral Classification 113
III Viral Replication and Genetics 113
IV Viral Pathogenesis 115
V Host Defenses to Viruses 119
VI Immunotherapy, Antivirals, and Interferon 120
VII Diagnostic Virology 125
VIII DNA Viruses 126
IX RNA Viruses 129
X Slow Viruses and Prions 138
XI Oncogenic Viruses 139
Review Test 141
6 System-Based and Situational Viral Infections 145
I Eye Infections 145
II Ear Infections 146
III Upper Respiratory Tract (Mouth and Throat) Infections 146
IV Lower Respiratory Tract Infections 147
V Gastrointestinal Infections 148
VI Liver Infection 149
VII Urinary Tract Infections (UTIs) 151
VIII Cardiovascular Infections 151
IX Nervous System Infections 151
X Skin, Mucosal, and Soft Tissue Infections 153
XI Childhood Infections 154
XII Congenital and Neonatal Infections 155
XIII Sexually Transmitted Diseases 156
XIV Postinfectious Disease 157
XV Organ Transplant-Associated Diseases 157
XVI Arboviral and Zoonotic Diseases 157
Review Test 158
7 Mycology 161
I Overview of Fungi 161
II Fungal Groups 165
III Overview of Fungal Diseases 165
IV Diagnosis of Fungal Infections 166
V Antifungal Drugs 167
Review Test 169
8 Fungal Diseases 170
I Superficial Skin Infections 170
II Cutaneous Mycoses 171
III Mucocutaneous Candidiasis 172
IV Subcutaneous Mycoses 173
V Pneumonias/Systemic Mycoses: Pathogens 173
VI Opportunistic Mycoses 177
VII Tables for Self-Testing 179
Review Test 181
9 Parasitology 186
I Characteristics of Parasites and Their Hosts 186
II Protozoan Parasites 186
III Worms 187
Review Test 189
10 Parasitic Diseases 190
Review Test 201
11 Clues for Distinguishing Causative Infectious Agents (Systems Approach) 205
I Conjunctivitis 205
II Pneumonias 205
III Diarrheas and Dysentery 210
IV Acute Meningitis 211
V Bacterial and Viral Skin Infection and Rashes 211
VI Genitourinary Tract Infections 213
VII System Summaries of Infectious Agents 224
A Characteristics of Important Causes of Encephalitis 224
B Characteristics of Important Causes of Meningitis 225
C Characteristics of Important Causes of Pneumonia 227
D Characteristics of Important Causes of Lower Respiratory Tract Infections 232
E Characteristics of Important Causes of Upper Respiratory Tract Infections 233
Review Test 235
12 Immunology 233
I Overview 238
II Non-Specific Barriers 239
III Inflammation and Soluble Factors 240
IV Mediators of Inflammation and Immunity 245
V Innate Immunity 246
VI Antibodies 252
VII Properties of Antibodies 254
VIII Immunogenetics 258
IX Adaptive Immunity 263
X Response to Antigen 270
XI Immunologic Assays 274
XII Clinical Immunological Disorders 277
Review Test 289
Comprehensive Examination: Block 1 294
Comprehensive Examination: Block 2 304
Comprehensive Examination: Block 3 314
Comprehensive Examination: Block 4 324
Index 335