Cellular Implications of Redox Signaling

by Avihai Danon, Carlos Gitler

Overview

Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells.

Product Details

ISBN-13:	9781860943317
Publisher:	Imperial College Press
Publication date:	08/28/2003
Pages:	440
Product dimensions:	6.00(w) x 9.00(h) x 1.10(d)

Table of Contents

	Preface	v
1	The Role of Thioredoxin and Glutaredoxin Systems in Disulfide Reduction and Thiol Redox Control	1
2	Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling	27
3	Iron-Sulfur Proteins: Properties and Functions	47
4	The Ferredoxin Ferredoxin/Thioredoxin Thioredoxin System. A light-Dependent Redox Regulatory System in Oxygenic Photosynthetic Cells	73
5	Thioredoxin and Redox Regulation: Beginnings in Photosynthesis Lead to a Role in Germination and Improvement of Cereals	99
6	The Role of Thioredoxin in Regulatory Cellular Functions	115
7	Protein S-Thiolation, S-Nitrosylation, and Irreversible Sulfhydryl Oxidation: Roles in Redox Regulation	141
8	Radical Scavenging by Thiols: Biological Significance and Implications for Redox Signaling and Antioxidant Defense	175
9	Ascorbate and Glutathione Metabolism in Plants: H[subscript 2]O[subscript 2]-Processing and Signalling	191
10	Disulfide Bond Formation in the Periplasm and Cytoplasm of Escherichia Coli	213
11	The Thiol Redox Paradox in the Requirement for Disulfide Isomerization in the Eukaryotic Endoplasmic Reticulum	233
12	Mechanisms Controlling Redox Balance in Cells. Inhibition of Thioredoxin and of Thioredoxin Reductase	257
13	Regulatory Disulfides Controlling Transcription Factor Activity in the Bacterial and Yeast Responses to Oxidative Stress	287
14	Redox Signaling During Light-Regulated Translation in Chloroplasts	311
15	Regulation of mRNA Translation and Stability in Iron Metabolism: Is there a Redox Switch?	327
16	Redox Flow as an Instrument for Gene Regulation	361
17	The Permeability Transition Pore as Source and Target of Oxidative Stress	393
	Author Index	421
	Subject Index	423