While working at a children's bookstore, DiCamillo wrote her first novel, Because of Winn-Dixie (2000). It was inspired by one of the worst winters in Minnesota, when she became homesick for Florida after overhearing a little girl with a southern accent. One thing led to another, and soon DiCamillo had created the voice of Opal Buloni, a resilient ten-year-old girl who has just moved to a small town in Florida with her father. Opal's mother abandoned the family when she was three years old, and her father has a hard time explaining why.

Thoug her father is busy and she has no friends, Opal's life takes a turn for the better when she adopts a fun-loving stray dog, Winn-Dixie (named after the supermarket where she found him, out in the parking lot). With Winn-Dixie as her guide, Opal makes friends with the eccentric people of her new town and even convinces her father to talk about her mother. Through Opal, readers are given a gift: a funny and heartrending story of how one girl's spirit can change her life and others'. Critics loved the book as much as readers, and in 2001, Because of Winn-Dixie was named a Newbery Honor Book.

DiCamillo's second novel, The Tiger Rising (2001), also deals with the importance of friendships, families, and making changes. Twelve-year-old Rob Horton and his father are dealing with grief, anger, and isolation after moving to Lister, Florida, six months after Rob's mother succumbs to cancer. Rob's father has a job at a motel (where they both also live), but it barely pays the bills. Struggling through the loss of his mother, Rob stifles his many confusing emotions as he battles bullies at his new school, worries about a rash on his legs, and copes with living in poverty.

In many ways, The Tiger Rising is a darker, more challenging story than Because of Winn-Dixie, but there is a similar light of deliverance in this beautiful novel: the healing power of friendship. Two meetings change Rob's life. First, he encounters a caged lion in the woods. Shortly thereafter he meets Sistine, who has recently moved to Lister after her parents' divorce. Sistine and Rob are polar opposites -- she stands up to the school bullies and lets out every bit of her anger at her parents' divorce and her relocation. Through Sistine, Rob recognizes himself in the caged lion, and the story of how the two children free the beast is one of the most engaging reads in contemporary young adult fiction. With the lion free, Rob is free to grieve the loss of his mother and move on with his bittersweet new life in Lister. A National Book Award finalist, The Tiger Rising is hard to put down as it overflows with raw, engaging emotion.

In 2003, DiCamillo's third novel, The Tale of Despereaux, was released to the delight of readers and critics alike. This odd but enthralling fairy tale also touches on some of the topics from her first two novels -- parental abandonment and finding the courage to be yourself. The hero, Despereaux Tilling, is a mouse who has always been different from the rest of his family, and to make matters worse, he has broken a serious rule: interacting with humans, particularly Princess Pea, who captures his heart. When Despereaux finds himself in trouble with the mouse community, he is saddened to learn that his father will not defend him. Characters in the tale are Princess Pea, whose mother died after seeing a rat in her soup; King Pea, who, in his grief, declares that no soup may be served anywhere in the kingdom; Miggery Sow, a servant girl who dreams of being a princess after being sold into servitude by her father after her mother dies; and Roscuro, a villainous rat with a curious soup obsession.

The story of how the characters' paths cross makes The Tale of Despereaux an adventurous read, reminiscent of Grimm's fairy tales. In the spirit of love and forgiveness, Despereaux changes everyone's life, including his own. As the unnamed, witty narrator of the novel tells us, "Every action, reader, no matter how small, has a consequence." Kate DiCamillo's limitless imagination and her talent for emotional storytelling earned her one of the most prestigious honors a children's author can receive -- in 2004, she was awarded the Newbery Medal.