Free Radicals: Biology and Detection by Spin Trapping

by Gerald M. Rosen, Bradley E. Britigan, Howard J. Halpern, Sovitj Pou

Overview

Free radicals, molecules with unpaired electrons, are highly reactive and play key roles in physiologic regulation and in many degenerative and pathologic processes, making them a fertile area of research. This book focuses on spin trapping, a sophisticated technique for the identification of free radicals in biological systems. The method is complex, and this book offers an in-depth guide to all of the critical aspects needed for its application to free radicals in biology. This includes advice on interpreting results, trouble-shooting, and experimental designs. The book looks at future directions in the field and will prove an invaluable resource for investigators working in the biology of free radicals, regardless of whether they are new or highly experienced in the applications of spin trapping.

Product Details

ISBN-13:	9780195095050
Publisher:	Oxford University Press, USA
Publication date:	01/01/1999
Pages:	464
Product dimensions:	6.10(w) x 9.30(h) x 1.10(d)

About the Author

University of Maryland School of Pharmacy

University of Iowa College of Medicine and VA Medical Center

University of Chicago Division of Biological Sciences and the School of Medicine

Medical Biotechnology Center of the University of Maryland Biotechnology Institute

Table of Contents

1. In the Beginning
2. The Oxygen Paradox
3. Nitric Oxide: A Simple Molecule with Complex Biological Functions
4. Methods of Free Radical Detection
5. Spin Trapping Free Radicals: Historical Perspective
6. The Synthesis of Spin Traps
7. Electron Paramagnetic Resonance Spectroscopy: Principles and Practical Aspects
8. Kinetics of Spin Trapping Free Radicals
9. The Chemistry of Spin Traps and Spin Trapped Adducts
10. Spin Trapping Free Radicals in Biological Systems
11. The Pharmacological Activity of Spin Traps
12. Future Directions
Notes
Index