Multiple Testing Procedures with Applications to Genomics / Edition 1

by Sandrine Dudoit, Mark J. van der Laan

Overview

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Product Details

ISBN-13:	9780387493169
Publisher:	Springer New York
Publication date:	12/19/2007
Series:	Springer Series in Statistics
Edition description:	2008
Pages:	590
Product dimensions:	0.00(w) x 0.00(h) x (d)

Table of Contents

Multiple Hypothesis Testing.- Test Statistics Null Distribution.- Overview of Multiple Testing Procedures.- Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn).- Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate.- Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Simulation Studies: Assessment of Test Statistics Null Distributions.- Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments.- Multiple Tests of Association with Biological Annotation Metadata.- HIV-1 Sequence Variation and Viral Replication Capacity.- Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project.- Software Implementation.

Editorial Reviews

From the reviews:

"This book summarizes the recent work of Sandrine Dudoit and Mark van der Laan on multiple testing. It proposes a general framework for multiple testing procedures (MTPs) and introduces new concepts … . The authors also provide code for reproducing the results of some of the applications. … if one is looking for a detailed summary of the latest developments in multiple testing regarding MTPs or in the application of MTPs to biomedical and genomic data, then this book is an excellent reference." (Holger Schwender, Statistical Papers, Vol. 50, 2009)

"In the last decade a growing amount of statistical research has been devoted to multiple testing. This book summarizes the recent work on this area. … very useful for the applied researcher who would like to understand how to apply multiple testing. … a good reference for statisticians interested in a general treatment of multiple testing." (Avner Bar-Hen, Mathematical Reviews, Issue 2009 j)

From the Publisher