Introduction to the Cellular and Molecular Biology of Cancer / Edition 4

by Margaret A. Knowles, Peter J. Selby, Peter Selby

Overview

This new edition o Introduction and Molecular Biology of Cancer provides a concise yet comprehensive overview of cancer biology, covering the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting, yet a broad understanding is essential for translation of laboratory findings into the clinic.
Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field, and the accompanying bibliographies allow rapid access to the relevant current literature. The book covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. Since the publication of the previous edition in 1997 there has been unprecedented progress in cancer research: this is reflected by an extensive revision of all the material, and the addition of eight new chapters, covering DNA repair, epigenetic events, the cell cycle, cell immortalization, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. The fourth edition of the popular book will serve as a text for both undergraduate and postgraduate use and also as an introduction for clinicians and scientists new to the field.

Product Details

ISBN-13:	9780198525639
Publisher:	Oxford University Press, USA
Publication date:	09/15/2005
Edition description:	REV
Pages:	552
Product dimensions:	9.60(w) x 7.30(h) x 1.40(d)

About the Author

Margaret Knowles is Professor of Experimental Cancer Research at the University of Leeds, and Associate Director of the Cancer Research UK Clinical Centre, also in Leeds. Peter Selby is Professor of Cancer Medicine and Director of the National Cancer Research Network at the University of Leeds.

Table of Contents

1. What is cancer?, L.M. Franks and Margaret A. Knowles
2. The causes of cancer, Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key
3. Inherited Susceptibility to Cancer, D. Timothy Bishop
4. DNA Repair and Cancer, Beate Köberle, John P. Wittschieben, and Richard D. Wood
5. Epigenetic Events in Cancer, Jonathan C. Cheng and Peter A. Jones
6. Molecular Cytogenetics of Cancer, Denise Sheer and Janet Shipley
7. Oncogenes, Margaret A. Knowles
8. Tumour suppressor genes, Sonia Lain and David P. Lane
9. The cancer cell cycle, Chris J. Norbury
10. Cellular immortalization and telomerase activation in cancer, Robert F. Newbold
11. Growth factors and their signalling pathways in cancer, Sally A. Prigent
12. Apoptosis: molecular physiology and significance for cancer therapeutics, Dean A. Fennell
13. Mechanisms of Viral Carcinogenesis, Paul Farrell
14. Cytokines and Cancer, Peter W. Szlosarek and Frances R. Balkwill
15. Hormones and cancer, Charlotte L. Bevan
16. The spread of tumours, Ian Hart
17. Angiogenesis, K.Tahtis and R.Bicknell
18. Stem cells, heamopoiesis, and leukaemia, Mel Greaves
19. Animal models of cancer, Jos Jonkers and Anton Berns
20. The immunology of cancer, Peter C. L. Beverley
21. The molecular pathology of cancer, Tatjana Crnogorac-Jurcevic, Richard Poulsom, and Nicholas R. Lemoine
22. From transcriptome to proteome, Silvana Debernardi, Rachel Craven, Bryan D. Young, and Rosamonde E. Banks
23. Local treatment of cancer, Ian S. Fentiman
24. Chemotherapy, D.R. Camidge and D.I. Jodrell
25. Radiotherapy and molecular radiotherapy, Anne Kiltie
26. Monoclonal antibodies and therapy, T. Geldart, M.J. Glennie, and P.W.M. Johnson
27. Immunotherapy of cancer, Andrew M. Jackson and Joanne Porte
28. Cancer gene therapy, John David Chester
29. Screening, Peter Sasieni and Jack Cuzick
30. Conclusions and prospects, Peter Selby and Margaret A Knowles

Editorial Reviews

"This book will be much appreciated by newcomers to cancer biology and will provide a concise and thought-provoking review for experts in the field."—Quarterly Review of Biology

From the Publisher