Table of Contents

I. Immunopathology.- 1. The cell of origin of Hodgkin’s disease.- 2. Hodgkin’s disease: Further information derived from cell lines.- 3. Origin and biologic function of Reed-Sternberg cells.- 4. Immunologic phenotypes of non-Hodgkin’s lymphomas: Correlation with morphology and function.- 5. Non-Hodgkin’s lymphoma with multilobated nuclei is not a distinct pathologic entity.- 6. Burkitt’s lymphoma: Multiparametric analysis of 55 cell lines with special reference to morphometry.- 7. Regulation of T-cell colony formation in the absence of added growth factors, in patients with T-cell malignancies.- II. Cytogenetics.- 1. Banded chromosome abnormalities in non-Hodgkin’s lymphoma. Correlations with morphology, immunologic phenotype and clinical course.- 2. Chromosomal aberrations in leukemic low-grade malignant B-cell lymphoproliferative neoplasias.- 3. Chromosome abnormalities in Burkitt lymphoma and Burkitt-type acute lymphoblastic leukemia.- 4. DNA content and proliferation in non-Hodgkin’s lymphoma: Flow cytofluorometric DNA analysis in relation to the Kiel classification.- 5. Oncogenes in human neoplasms.- 6. Stage specific transforming genes in lymphoid neoplasms.- III. Biochemical markers.- 1. DNA synthetic and degradative pathways in malignant lymphomas.- 2. Enzymes involved in adenosine metabolism in normal or leukemic lymphocytes.- 3. Purine metabolism in normal and pathologic lymphoid cell differentation.- 4. Purine degradative enzymes in the malignant cells of patients with B-cell leukemia.- 5. Lymphocyte uroporphyrinogen synthase activity as a diagnostic test in lymphoproliferative disorders — preliminary results.- 6. Enzymatic and ultrastructural properties of the plasma membrane in human leukemias, in non-Hodgkin’s lymphomas and in human lymphoblastoid cells.- IV. Clinico-pathologic correlations.- 1. Prognostic significance of cytologic subdivision in nodular sclerosing Hodgkin’s disease: An analysis of 1156 patients.- 2. Comparison of the Working Formulation of non-Hodgkin’s lymphoma with the Rappaport, the Kiel, and the Lukes-Collins Classifications. Correlations and prognostic value.- 3. Bone marrow and blood involvement by non-Hodgkin’s lymphoma: Clinicopathologic features and prognostic significance in relationship to the Working Formulation.- 4. Clonal blood B-cell excess in relation to prognosis in untreated non-leukemic patients with non-Hodgkin’s lymphoma (NHL).- 5. Patterns of survival in advanced non-Hodgkin’s lymphoma.- V. Special clinical entities.- 1. Acquired Immune Deficiency Syndrome (AIDS): Basic findings.- 2. Malignant lymphoma in homosexual men: Relationship to Acquired Immune Deficiency Syndrome (AIDS).- 3. Unusual presentations of non-Hodgkin’s lymphomas in homosexual males.- 4. Immunoproliferative small intestinal disease.- VI. Treatment of Hodgkin’s disease.- 1. The current status of the Stanford randomized clinical trials of the management of Hodgkin’s disease.- 2. The current status of NCI trials in Hodgkin’s disease.- 3. Current status of the Milan trials for Hodgkin’s disease in adults.- 4. Indications for combined modality therapy in patients with Hodgkin’s disease.- 5. Combined modality treatment of Hodgkin’s disease confined to lymph nodes. Results 14 years later.- 6. Treatment of early stage Hodgkin’s disease: A randomized trial of radiotherapy plus chemotherapy versus chemotherapy alone.- 7. Randomized study of chemotherapy alone vs. chemotherapy plus radiotherapy in Clinical Stages IA-IIA Hodgkin’s Disease.- 8. Chemotherapy alone versus combined modality therapy for Stage III Hodgkin’s disease: A five-year follow-up of a Southwest Oncology Group study (SWOG-7518) USA.- 9. Chemotherapy plus radiotherapy in clinical Stages IA to IIIB Hodgkin’s disease. Results of the H 77 trial (1977-1980).- 10. Surgical restaging after 3 or 6 courses of MOPP chemotherapy in Hodgkin’s disease.- 11. Staging laparotomy with splenectomy in Stage I and II Hodgkin’s disease. No therapeutic benefit.- 12. Comparison of initial splectomy and spleen irradiation in clinical Stages I and II Hodgkin’s disease.- 13. Prognostic groups for management of clinically localized Hodgkin’s disease.- 14. Management of localized, infradiaphragmatic Hodgkin’s disease: Experience of a rare clinical presentation at St. Bartholomew’s Hospital.- 15. Chemotherapy (MVPP) for Stage IIB/IV Hodgkin’s disease with an assessment of prognostic factors.- 16. Incidence of liver involvement and correlation of biopsy results with Ann Arbor clinical criteria and response to chemotherapy in advanced Hodgkin’s disease: A Southwest Oncology Group study.- 17. Second cancers after treatment in two successive cohorts of patients with early stages of Hodgkin’s disease.- 18. Late complications of cytotoxic chemotherapy given for advanced Hodgkin’s disease.- VII. Treatment of non-Hodgkin’s lymphomas.- 1. Overview on current strategy of the treatment of non-Hodgkin’s lymphomas.- 2. The low grade non-Hodgkin’s lymphomas: Current approaches to therapy.- 3. Treatment of diffuse large cell non-Hodgkin’s lymphomas.- 4. The use of chemotherapy for localized large cell lymphoma Results from the University of Arizona.- 5. A randomized comparison of two chemotherapy regimes: BACOP vs COPP in the treatment of diffuse histiocytic and mixed lymphoma.- 6. Results of ifosfamide-Etoposide combinations for patients with recurrent or refractory aggressive lymphoma.- 7. New Agents for Hodgkin’s and non-Hodgkin’s lymphomas.- 8. Autologous stem cell transplant for poor prognosis lymphoma.- 9. In vitro purging with 4-hydroperoxycyclophosphamide and its effects on the hematopoietic and stromal elements of human bone marrow.- 10. Treatment of refractory non-Hodgkin’s lymphoma with intensive chemo-radiotherapy and autologous bone marrow transplantation.- 11. Transplantation with anti-B1 monoclonal antibody and complement treated autologous bone marrow for relapsed B-cell non-Hodgkin’s lymphoma.- 12. The immunobiology of B-cell lymphoma. Studies with anti-idiotype antibodies.- 13. Therapeutic use of monoclonal anti-idiotype antibodies against B-cell lymphoma.- 14. Radioimmunodetection of human B-cell lymphomas with a radiolabeled tumor-specific monoclonal antibody (Lym-1).- 15. Treatment of cutaneous T-cell lymphomas with biologic response modifiers: Recombinant leukocyte A interferon and T101 monoclonal antibody.- 16. Clinical interferon (IFN) studies in leukemia and lymphoma.- VIII. Treatment of childhood lymphomas.- 1. Current status of the curability of children with Hodgkin’s disease: An assessment of the risk: benefit ratio of modern therapy.- 2. Treatment of childhood Stages I and II Hodgkin’s disease without radiotherapy.- 3. Combined modality treatment with reduced chemotherapy and radiotherapy, and selective splenectomy, in children with Hodgkin’s disease.- 4. Strategies for management of childhood non-Hodgkin’s lymphomas based upon stage and immunopathologic subtype; Rationale and current results.- 5. BFM trials for childhood non-Hodgkin’s lymphomas.- 6. Characteristics and results of treatment of non-Hodgkin’s lymphoma in young people — Experience of the Pediatric Branch, NCI, USA.