Molecular Biology of Aging: (Cold Spring Harbor Monograph Series 51)

by Leonard Guarente, Douglas C. Wallace

Overview

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.

Product Details

ISBN-13:	9780879698249
Publisher:	Cold Spring Harbor Laboratory Press
Publication date:	11/19/2007
Series:	Cold Spring Harbor Monograph Series
Edition description:	New Edition
Pages:	624
Product dimensions:	6.20(w) x 9.30(h) x 1.20(d)

Table of Contents

Preface     vii
The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases   D.C Wallace     1
Sirtuins: A Universal Link between NAD, Metabolism, and Aging   S.-i. Imai   L.P. Guarente     39
Calorie Restriction in Lower Organisms   S.L. Helfand   J.H. Bauer   J.G. Wood     73
Evolutionary Theory in Aging Research   S.N. Austad   T.B.L. Kirkwood     95
An Overview of the Biology of Aging: A Human Perspective   G.M. Martin   C.E. Finch     113
p53, Cancer, and Longevity   L.A. Donehower   A.J. Levine     127
Aging Processes in Caenorhabditis elegans   H.A. Tissenbaum   T.E. Johnson     153
Cellular Senescence: A Link between Tumor Suppression and Organismal Aging?   J.M. Sedivy   U.M. Munoz-Najar   J.C. Jeyapalan   J. Campisi     185
Genome-wide Views of Aging Gene Networks   S.K. Kim     215
Aging in Mammalian Stem Cells and Other Self-renewing Compartments   D.J. Rossi   N.E. Sharpless     237
Yeast, a Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging   L. Partridge   J. Tower     267
DNA Repair and Aging   V.A. Bohr   D.M. Wilson III   N.C de Souza-Pinto   I. van der Pluijm   J.H. Hoeijmakers     309
Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis   J.J. Kopchick   A. Bartke   D.E. Berryman     347
Alzheimer's Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics   P.C. Wong   D.L. Price   L. Bertram   R.E. Tanzi     371
How Does Caloric Restriction Increase the Longevity of Mammals?   R. Weindruch   R.J. Colman   V. Perez   A.G. Richardson     409
Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress   G.J. Lithgow   R.A. Miller     427
Molecular Mechanisms of Aging: Insights from Budding Yeast   S.-J. Lin   D. Sinclair     483
Genetics of Exceptional Longevity   T.T. Perls   P. Sebastiani     517
Mammalian Metabolism in Aging   P. Puigserver   C.R. Kahn     545
Telomeres and Telomerase in Aging and Cancer   J.W. Shay   W.E. Wright     575
Index     599

Editorial Reviews

This excellent book provides an overview of the state of the field. Many of the people who contributed to the transformation of the biology of aging came together to review this topic...This results in a very complete book on the biology of aging that should serve as an excellent resource for both researchers and students.

The Quarterly Review of Biology