Table of Contents
Section I. Unraveling pathways of clinical function and disability
1. Role of prion protein during normal physiology and disease, Adriana Simon Coitinho and Glaucia N. M. Hajj
2. Role of protein kinase C and related pathways in vascular smooth muscle contraction and hypertension, Xiaoying Qiao and Raouf A. Khalil
3. Brain temperature regulation during normal neural function and neuropathology, Eugene A. Kiyatkin
4. Retinal cellular metabolism and its regulation and control, Dao-Yi Yu, Stephen J Cringle, Paula K Yu, Er-Ning Su, Xinghuai Sun, Wenyi Guo, William H Morgan Xiao-Bo Yu, and Chandrakumar Balaratnasingam
5. Crosstalk between the autonomic nervous system and the central nervous system: Mechanistic and therapeutic considerations for neuronal, immune, vascular, and somatic based diseases, Fuad Lechin and Bertha van der Dijs
6. Neurobiology of chronic pain, Min Zhuo
7. Physiological effects and disease manifestations of performance enhancing androgenic-anabolic steroids, growth hormone, and insulin, Michael R. Graham, Julien S. Baker, Peter Evans, and Bruce Davies
Section II. The potential of stem and progenitor cell applications for degenerative disorders
8. Mesenchymal stem cells and transdifferentiated neurons in crosstalk with the tissue microenvironment: Implications for translational science, Katarzyna A. Trzaska, Steven J. Greco, Lisamarie Moore, Pranela Rameshwar
9. Motoneurons from human embryonic stem cells: Present status and future strategies for their use in regenerative medicine, K.S. Sidhu
10. Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells, Philippe Taupin
11. Glutamatergic signaling in neurogenesis, Noritaka Nakamichi and Yukio Yoneda
Section III. Elucidating inflammatory mediators of disease
12. Neuroimmune interactions that operate in the development and progression of inflammatory demyelinating diseases: Lessons from pathogenesis of multiple sclerosis, Enrico Fainardi and Massimiliano Castellazzi
13. Brain inflammation and the neuronal fate: From neurogenesis to neurodegeneration, Maria Antonietta Ajmone-Cat, Emanuele Cacci, and Luisa Minghetti
14. Immunomodulation in the nervous and vascular systems during inflammation and autoimmunity: The role of T regulatory cells, Kokona Chatzantoni and Athanasia Mouzaki
Section IV. Translating novel cellular pathways into viable therapeutic strategies
15. Alzheimers disease - Is it caused by cerebrovascular dysfunction?, Christian Humpel
16. Proteases in beta-amyloid metabolism: Potential therapeutic targets against Alzheimer's disease, Noureddin Brakch and Mohamed Rholam
17. Neurobiology of Post-Ischemic Recuperation in the Aged Mammalian Brain, Aurel Popa-Wagner, Adrian Balseanu, Leon Zagrean, Imtiaz M. Shah, Mario Di Napoli, Zaal Kokaia and Henrik Ahlenius
18. Protein misfolding, mitochondrial disturbances and kynurenines in the pathogenesis of neurodegenerative disorders, Gabriella Gárdián, Katalin Sas, József Toldi and László Vécsei
19. Redox signaling and vascular function, J. Will Langston, Magdalena L. Circu and Tak Yee Aw
20. Gene therapy toward clinical application in the cardiovascular field, Hironori Nakagami, Mariana Kiomy Osako, and Ryuichi Morishita
21. Role of advanced glycation end products, oxidative stress, and inflammation in diabetic vascular complications, Sho-ichi Yamagishi, Takanori Matsui, Kazuo Nakamura
22. Reducing oxidative stress and enhancing neurovascular longevity during diabetes mellitus, Kenneth Maiese, Zhao Zhong Chong, and Faqi Li