Nipple Aspirate Fluid Exfoliative Cytopathology and Molecular Biomarkers: Current Role in the Management of Breast Health

by J#x000FC;rgen Beyerer, Matthias Nagel

Overview

Nipple Aspirate Fluid Exfoliative Cytopathology and Molecular Biomarkers: Current Role in the Management of Breast Health gives a comprehensive overview of the current and past uses of nipple aspirate fluid (NAF) in breast cancer diagnosis and risk assessment. Topics covered include: • NAF collection methods • analytical validity of NAF cytology • the role of NAF cytology in breast cancer risk stratification • molecular biomarkers found in NAF • risk stratification based on molecular biomarkers in NAF • the effects of therapeutic interventions on NAF cytology and biomarkers • pharmacoeconomic evaluation of NAF-based risk assessment • clinical validity and clinical utility of NAF cytopathology Nipple Aspirate Fluid Exfoliative Cytopathology and Molecular Biomarkers is a primer on the advances that have been made regarding NAF cytology and molecular biomarkers, discussing new innovations in the context of past discoveries. It contains indispensable information about a field of breast cancer research that investigators and clinicians alike should be aware of.

Product Details

ISBN-13:	9780996849609
Publisher:	BookBaby
Publication date:	03/03/2016
Pages:	292
Product dimensions:	6.20(w) x 9.10(h) x 0.80(d)

About the Author

Steven Quay is the chairman, president, and CEO of Atossa Genetics, a leader in developing innovative breast health products and services. Dr Quay is board certified in Anatomic Pathology and has authored more than 130 papers on topics such as RNA interference, diagnostic imaging, oncology and biochemistry.

Table of Contents

Acknowledgments i

1 Breast Cancer and Nipple Aspirate Fluid: The Basics 1

2 Physiology and Pathology of Non-Lactational NAF 23

3 Methods of NAF Collection 43

4 Exfoliative Cytopathology of NAF: Analytical Validity and Observational Studies 61

5 Comparative Studies of Pathology of Invasive Breast Biopsy and Exfolitative Cytopathology of NAF 71

6 Comparative Studies of Breast Imaging Studies (Including Ductoscopy) and Exfolitative Cytopathology of NAF 79

7 Longitudinal Studies of Breast Cancer Risk Stratification using Exfolitative Cytopathology of NAF 91

8 Molecular Biomarkers in NAF: Observational Studies 113

9 Longitudinal Studies of Breast Cancer Risk Stratification using Molecular Biomarkers in NAF 127

10 Modification of NAF Cytopathology and Biomarkers by Therapeutic Interventions 135

11 Pharmacoeconomic Studies of the Utility of NAF Analysis in Risk Stratification 151

12 Clinical Validity and Clinical Utility of NAF Cytopathology 159

13 Summary 171

Breast Fine Needle Aspirate Slides 177

Index 243

Reference List 251