Pancreatic Beta Cell in Health and Disease / Edition 1

by Susumu Seino, Graeme I. Bell

Overview

The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis, regulating glucose uptake in muscle and adipose tissue as well as carbohydrate, fat, and protein metabolism in these tissues and the liver. This book provides a comprehensive up-to-date review of the beta cell in health and disease. Chapters address the architecture and pathology of normal and diabetic pancreatic islets; regulation of beta-cell proliferation and death; the potential of stem cells and extra-pancreatic tissues as beta-cell replacement therapies; insulin biosynthesis; regulation of insulin secretion including metabolic control, ion channels, gap junctions, cyclic AMP, incretins, and exocytosis; development of novel imaging techniques; and genetic disorders of the beta cell. A primary aim of the book is to encourage students and young basic and clinical investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

Product Details

ISBN-13:	9784431754510
Publisher:	Springer Japan
Publication date:	12/18/2007
Edition description:	2008
Pages:	476
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Preface V

Contributors XI

I Pancreatic Beta Cell and Insulin Biosynthesis

1 Architecture of Pancreatic Islets M. Brissova A.C. Powers 3

2 Transcriptional Regulation of Insulin Gene Expression I. Artner R. Stein 13

3 The Biosynthesis of Insulin D.F. Steiner 31

II Cell Signaling and Insulin Secretion

4 Metabolic Regulation of Insulin Secretion B.E. Corkey 53

5 Mechanisms of Beta-Cell Death in Diabetes M.Y. Donath J.A. Ehses 75

6 Ion Channels and Insulin Secretion D.A. Jacobson L.H. Philipson 91

7 Gap Junctions and Insulin Secretion P. Klee S. Bavamian A. Charollais D. Caille J. Cancela M. Peyrou P. Meda 111

8 Protein Kinase A-Independent Mechanism of cAMP in Insulin Secretion S. Seino T. Miki T. Shibasaki 133

9 Regulation of Insulin Granule Exocytosis E. Renstrom P. Rorsman 147

10 Mechanism of Insulin Exocytosis Analyzed by Imaging Techniques S. Nagamatsu M. Ohara-Imaizumi 177

11 Two-Photon Excitation Imaging of Insulin Exocytosis N. Takahashi H. Kasai 195

III Pancreatic Development and Beta-Cell Formation

12 Regulation of Beta-Cell Growth and Death C.J. Rhodes 215

13 Beta-Cell Replication S.J. Salpeter Y. Dor 245

14 Stem Cells as a Cure for Diabetes T. Otonkoski, M. Banerjee K. Lundin 265

15 Use of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes I. Meivar-Levy S. Ferber 285

IV Incretins and Beta-Cell Function

16 Molecular Biology of Gluco-Incretin Function S. Klinger B. Thorens 315

17 Incretins and Regulation of Insulin Secretion M.A. Nauck J.J. Meier 335

V Pancreatic Beta Cell and Disease

18 Pancreatic Islet Pathology in Type 2 Diabetes A. Clark 381

19 Genetic Disorders of the Pancreatic Beta Cell and Diabetes (PermanentNeonatal Diabetes and Maturity-Onset Diabetes of the Young) E.L. Edghill A.T. Hattersley 399

20 ATP-Sensitive Potassium Channels in Health and Disease P. Proks F.M. Ashcroft 431

21 Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor F.M. Matschinsky 451

Subject Index 465