Platelet-Activating Factor Acetylhydrolases (PAF-AH)

by Elsevier Science

Overview

This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field of enzymes

Product Details

ISBN-13:	9780128039465
Publisher:	Elsevier Science
Publication date:	12/01/2015
Series:	Enzymes , #38
Sold by:	Barnes & Noble
Format:	eBook
Pages:	222
File size:	13 MB
Note:	This product may take a few minutes to download.

About the Author

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology&Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.
Dr. Diana Stafforini works at the Huntsman Cancer Institute at the University of Utah School of Medicine.
Professor Inoue works at the Teikyo University, School of Pharmacy, Japan.

Table of Contents

1. Overview of PAF Degrading Enzymes
   Ken Karasawa and Keizo Inoue
2. Intracellular PAF Acetylhydrolase Type I
   Mitsuharu Hattori and Hiroyuki Arai
3. Platelet-Activating Factor Acetyl Hydrolase and Brain Development
   Gary D. Clark
4. Intracellular Platelet Activating Factor (PAF) Acetylhydrolase, Type II: A  Unique Cellular Phospholipase A2 that Hydrolyzes Oxidatively-Modified Phospholipids
   Nozomu Kono and Hiroyuki Ara
5. Trafficking and Oligomeric Regulation of Platelet-Activating Factor         Acetylhydrolase Type II
   Meghan M. Klems and Brian J. Bahnson
6. Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression
   Diana M. Stafforini
7. Crystal Structure and Atomic Level Analysis of Plasma PAF-AH 
   Tara D. Gonzalez and Brian J. Bahnson
8. Naturally Occurring Missense Mutation in Plasma PAF-AH Among the  Japanese Population
   Ken Karasawa
9. Plasma PAFAH/PLA2G7 Genetic Variability, Cardiovascular Disease and Clinical Trials
   Sonia Karabina and Ewa Ninio
10. Diverse Functions of Plasma PAF-AH in Tumorigenesis
    Diana M. Stafforini