Postgraduate Haematology

by A. Victor Hoffbrand (Editor), Douglas R. Higgs (Editor), David M. Keeling (Editor), Atul B. Mehta (Editor)

Overview

Highly Commended at the British Medical Association Book Awards 2016

Postgraduate Haematology provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style.

• Up-to-date knowledge of the pathogenesis, clinical and laboratory features and management of all blood disorders
• New sections reflect advances in the specialty, including knowledge gained from new generation sequencing, latest anticoagulant drugs, diagnostic laboratory tools, and treatment strategies
• Superb four-color illustrations and photomicrographs of blood cells and tissues throughout
• Includes algorithms to aid with decision-making for treatment
• Companion website includes figures and tables for download

Product Details

ISBN-13:	9781118853801
Publisher:	Wiley
Publication date:	10/28/2015
Sold by:	Barnes & Noble
Format:	eBook
Pages:	952
File size:	40 MB
Note:	This product may take a few minutes to download.

About the Author

A. Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci
Emeritus Professor of Haematology at University College London, London, UK

Douglas R. Higgs MD, FRCP, FRS
Professor of Molecular Haematology&Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK 

David Keeling
Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK

Atul B. Mehta MA, MD, FRCP, FRC Path
Consultant Haematologist&Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK

Table of Contents

Contributor list vii

Preface to the seventh edition x

Preface to the first edition xi

1 Stem cells and haemopoiesis 1
Emma de Pater, Elaine Dzierzak

2 Erythropoiesis 11
Douglas R Higgs, Noémi Roy, Deborah Hay

3 Iron metabolism iron deficiency and disorders of haem synthesis 21
Clara Camaschella, A Victor Hoffbrand, Chaim Hershko

4 Iron overload 40
Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini

5 Megaloblastic anaemia 53
A Victor Hoffbrand

6 Haemoglobin and the inherited disorders of globin synthesis 72
Swee Lay Thein, David Rees

7 Sickle cell disease 98
Anne Marsh, Elliott P Vichinsky

8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114
Paola Bianchi, Narla Mohandas

9 Acquired haemolytic anaemias 138
Modupe O Elebute, Rachel Kesse-Adu

10 Inherited aplastic anaemia/bone marrow failure syndromes 156
Inderjeet S Dokal

11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174
Judith CW Marsh, Austin G Kulasekararaj,, Neal S Young, Peter Hillmen

12 Red cell immunohaematology 195
Geoff Daniels, Marcela Contreras, Shubha Allard

13 Clinical blood transfusion 214
Shubha Allard, Marcela Contreras

14 Phagocytes 246
John Mascarenhas, Marina Kremyanskaya,, Ronald Hoffman

15 Lysosomal storage disorders 270
Atul B Mehta, Derralynn A Hughes

16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278
Paul Moss, Mark Drayson

17 The spleen 303
Paul Moss

18 The molecular basis of haematological malignancies 314
Niccolo Bolli, George Vassiliou

19 Laboratory diagnosis of haematological neoplasms 332
Torsten Haferlach, Barbara J Bain

20 Acute myeloid leukaemia 352
Alan K Burnett, David Grimwade

21 Adult acute lymphoblastic Llukaemia 371
Clare J Rowntree, Adele K Fielding

22 Childhood acute lymphoblastic leukaemia 384
Ajay Vora

23 Supportive care in the management of leukaemia 399
Eliza Gil, Vanya Gant, Panagiotis Kottaridis

24 Chronic myeloid leukaemia 419
David TO Yeung, Timothy P Hughes

25 The myelodysplastic syndromes 438
Kavita Raj, Ghulam J Mufti

26 Myeloproliferative neoplasms 474
Peter J Campbell, Claire Harrison, Anthony R Green

27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500
Emili Montserrat, Peter Hillmen

28 T-cell lymphoproliferative disorders 524
Pier Luigi Zinzani, Alessandro Broccoli

29 Multiple myeloma 537
Jesús San-Miguel, Joan Bladé

30 Amyloidosis 562
Simon DJ Gibbs, Philip N Hawkins

31 The classification of lymphomas: updating the WHO classification 575
Elias Campo, Stefano A Pileri

32 Hodgkin lymphoma 601
Piers Blombery, David Linch

33 Non-Hodgkin lymphoma: low grade 614
William Townsend, Robert Marcus

34 Non-Hodgkin lymphoma: high grade 631
Jessica Okosun, Kate Cwynarski

35 Stem cell transplantation 651
Charles Craddock, Ronjon Chakraverty

36 Normal haemostasis 676
Keith Gomez, John H McVey

37 The vascular function of platelets 699
Stephen P Watson, Neil V Morgan, Paul Harrison

38 Haemophilia and VonWillebrand disease 715
Michael A Laffan, K John Pasi

39 Rare inherited coagulation disorders 733
Flora Peyvandi, Marzia Menegatti

40 Acquired coagulation disorders 743
Peter W Collins, Jecko Thachil, Cheng-Hock Toh

41 Congenital platelet disorders 761
Maurizio Margaglione, Paul RJ Ames

42 Primary immune thrombocytopenia 773
Drew Provan, Adrian C Newland

43 Thrombotic thrombocytopenic purpura and haemolytic–uraemic syndrome (congenital and acquired) 783
Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla

44 Heritable thrombophilia 795
Trevor Baglin, David Keeling

45 Acquired venous thrombosis 809
Beverley J Hunt, Henry G Watson

46 Antithrombotic agents 820
Trevor Baglin, David Keeling

47 Management of venous thromboembolism 830
Trevor Baglin, David Keeling

48 Haematological aspects of systemic disease 838
A Victor Hoffbrand, Atul B Mehta

49 Haematological aspects of tropical diseases 854
Imelda Bates, Ivy Ekem

50 Neonatal haematology 870
Irene Roberts, Subarna Chakravorty

51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885

Index 888

What People are Saying About This

From the Publisher

Quotes from review in the New England Journal of Medicine

"Hoffbrand, Catovsky, and Tuddenham have managed to bring together a new edition (the fifth) of Postgraduate Haemotology in every chapter of which the reader finds very good, updated discussions..."

"The editors have asked outstanding experts in every field to write new chapters or update previously included chapters."

"Most hematologists need a revised and practical textbook in which they can rapidly search on the morning of a consultation.........This book will be an important resource in such situations."

Quotes from review in the European Journal of Haematology

"...revised and transformed to appear today as the fifth edition of a modern and fully updated source of information for haematologist in training and consultants."

"The book reflects the many and challenging professional aspects of being a specia-list in blood disorders. Reading the book as part of the postgraduate education and using the book as a readily accessible source of information will definitely contri-bute to confirm doctors in training and consultants why it is right to choose and practice haematology."

Other Quotes

"...this text undoubtedly provides an essential reference fro final-year Bsc, Msc and postgraduate research students specialising in haematology. All 1073 pages of it!"
British Journal of Biomedical Science

‘Most haematologists need a revised and practical textbook in which they can rapidly search on the morning of a consultation… This book will be an important resource in such situations.’ – New England Journal of Medicine

‘…revised and transformed to appear today as the fifth edition of a modern and fully updated source of information for haematologist in training and consultants.’ – European Journal of Haematology

Editorial Reviews

"Completely revised to reflect the latest research in the field, this edition continues to provide trainees with up-to-date knowledge on the pathogenesis, clinical and laboratory features, and management of blood disorders. It covers the significant advances which have occurred in the application of cytogenetics and molecular genetics in the diagnosis, classification and understanding of haematological disorders ." (TMCnet.com, 8 December 2010)

Quotes from review in the New England Journal of Medicine

"Hoffbrand, Catovsky, and Tuddenham have managed to bring together a new edition (the fifth) of Postgraduate Haemotology in every chapter of which the reader finds very good, updated discussions..."

"The editors have asked outstanding experts in every field to write new chapters or update previously included chapters."

"Most hematologists need a revised and practical textbook in which they can rapidly search on the morning of a consultation.........This book will be an important resource in such situations."

Quotes from review in the European Journal of Haematology

"...revised and transformed to appear today as the fifth edition of a modern and fully updated source of information for haematologist in training and consultants."

"The book reflects the many and challenging professional aspects of being a specia-list in blood disorders. Reading the book as part of the postgraduate education and using the book as a readily accessible source of information will definitely contri-bute to confirm doctors in training and consultants why it is right to choose and practice haematology."

Other Quotes

"...this text undoubtedly provides an essential reference fro final-year Bsc, Msc and postgraduate research students specialising in haematology. All 1073 pages of it!"
British Journal of Biomedical Science

‘Most haematologists need a revised and practical textbook in which they can rapidly search on the morning of a consultation… This book will be an important resource in such situations.’ – New England Journal of Medicine

‘…revised and transformed to appear today as the fifth edition of a modern and fully updated source of information for haematologist in training and consultants.’ – European Journal of Haematology

 

From the Publisher