Principles of Bone Biology

by John P. Bilezikian (Editor), Lawrence G. Raisz (Editor), T. John Martin (Editor)

Overview

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

• Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants…it is all in one source written by the experts in the field
• The essential resource for anyone involved in the study of bones and bone diseases
• Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics
• Readers can easily search and locate information quickly as it will be online with this new edition

Product Details

ISBN-13:	9780080568751
Publisher:	Elsevier Science
Publication date:	09/29/2008
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1900
File size:	23 MB
Note:	This product may take a few minutes to download.

About the Author

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians&Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians&Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.
Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.
Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.

Read an Excerpt

The most current and timely source of information about the biology and pathobiology of bone.

Table of Contents

Part I Basic Principles A. Cell Biology Chapter 1:  Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Chapter 2: Biomechanics of Bone Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Chapter 4: Mesenchymal Stem Cells&Osteoblast Lineage Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Chapter 6: Wnt Signaling and Bone Chapter 7: Sclerostin and Bone Chapter 8: The Osteocyte Chapter 9: Cells of Bone: Osteoplast Generation Chapter 10: Osteoclast Function: Biology and Mechanisms Chapter 11: RANK Signaling Chapter12: Regulating Bone Resorption Chapter 13: Apoptosis in Bone Cells Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments B. Biochemistry Chapter 15:  Type I Collagen: Structure, Synthesis, and Regulation Chapter 16: Collagen Crosslinking&Metabolism Chapter 17: Bone Matrix Proteoglycans&Glycoproteins Chapter 18: Osteopontin Chapter 19: Bone Proteinases Chapter 20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells Chapter 21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis Chapter 22: Histomorphometric Analysis of Bone Remodeling Chapter 23: Phosphorus Homeostasis&Related Disorders Chapter 24: Magnesium Homeostasis Chapter 25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon,&Stro Chapter 26: Biology of the Extracellular Ca2+-Sensing Receptor D. The Hormones of Bone Chapter 27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein Chapter 28: Parathyroid Hormone - Molecular Biology Chapter 29: Parathyroid Hormone-Receptor Interactions Chapter 30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System Chapter 31: The Vascular and Cardiovascular Actions of PTH Chapter 32: PTH and PTHrP Actions on Kidney and Bone Chapter 33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Chapter 36: Vitamin D Gene Regulation Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Chapter 39: Amylin and Calcitonin Gene-Related Peptide E. Other Systemic Hormones That Influence Bone Metabolism Chapter 40: Estrogens&Progestins Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Chapter 42: Mechanisms of Estrogen Action in Bone Chapter 43: Thyroid Hormone&Bone Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Chapter 45: Effects of Diabetetes&Insulin on Bone Physiology Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Chapter 47: Kinins&Neuro-Osteogenic Factors Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy F. Local Regulators Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Chapter 50: Platelet-Derived Growth Factor&the Skeleton Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Chapter 53: Transforming Growth Factor-â Chapter 54: Bone Morphogenetic Proteins and the Skeleton Chapter 55: Bone Morphogenetic Protein Receptors&Actions Chapter 56: Colony-Stimulating Factor-1 Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Chapter 58: Prostaglandins&Bone Metabolism Carol Pilbeam Part II Molecular Mechanisms of Metabolic Bone Disease Chapter 59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis Chapter 60: Molecular Basis of PTH Overexpression Chapter 61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism Chapter 62: Multiple Endocrine Neoplasia Type I Chapter 63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy Chapter 64: Local Factors in Skeletal Malignancy Chapter 65: Genetic Regulation of the Parathyroid Gland Development Chapter 66: Jansen's Metaphyseal Chondrodysplasia&Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations Chapter 67: Diseases Resulting from Defects in the G Protein Gs Chapter 68: Renal Osteodystrophy – Pathogenic Mechanisms and Therapeutic Options Chapter 69: Osteogenesis Imperfecta Chapter 70: Hereditary Deficiencies in Vitamin D Action Chapter 71: Oncogenic Osteomalacia Chapter 72: Osteopetrosis Chapter 73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans Chapter 74: Paget's Disease of Bone Chapter 75: Genetic Determinants of Bone Mass and Osteoporotic Fracture Chapter 76: Pathophysiology of Osteoporosis Chapter 77: Evaluation of Risk for Osteoporosis Fracture Part III Pharmacological Mechanisms of Therapeutics Chapter 78: Parathyroid Hormone Chapter 79: Calcium Chapter 80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics Chapter 81: Bisphosphonates: Mechanisms of Action Chapter 82: The Pharmacology of Estrogens in Osteoporosis Chapter 83: Vitamin D&Analogs Chapter 84: Estrogen Effects on Bone in the Male Skeleton Chapter 85: Mechanisms of Exercise Effects on Bone Quantity and Quality

Part IV Methods in Bone Research Chapter 86: Application of Transgenic Mice to Problems of Skeletal Bone Chapter 87: Biochemical Markers of Bone Metabolism Chapter 88: Methods and Clinical Issues in Bone Densitometry Chapter 89: Controversial Issues in Bone Densitometry Chapter 90: Macro and Micro Imaging of Bone Architecture

Editorial Reviews

4 Stars! from Doody

This is the first edition of an excellent monograph summarizing the major recent advances occurring in the field of bone biology. The book covers four areas: basic principles of bone biology; molecular mechanisms of metabolic bone disease; pharmacologic mechanisms of therapeutics; and methods in bone research. The book attempts to provide a new repository of knowledge concerning the revolution in bone biology. This is certainly a worthy objective, because there is a large volume of new basic information in the field. The book meets the editors' main objective very well. The intended audience is students, postdoctoral fellows, young investigators, and established scientists in the field of bone biology. A wider secondary audience will be clinicians caring for patients with metabolic bone disorders who desire to develop a deeper understanding of their patients' diseases. The editors are individually very credible authorities in this field, with many of the contributing authors internationally recognized experts in their own areas. The book is clearly and appropriately illustrated with black-and-white drawings and photographs and color prints. References are current and pertinent. The table of contents is very well organized, and the index provides sufficient detail to help the reader find almost any topic covered in the book. The book has a somewhat bland gray cover. An attractive feature of the book is the fairly liberal use of color plates to demonstrate points related to bone histomorphometry and skeletal details in various animal knockout models. This monograph will be useful to both new and accomplished students of bone biology, and to some degree, to the practicing clinicianwith an interest in metabolic bone disease. It fills a major void not occupied by several other recently published textbooks in the field, and it is likely to become the standard against which future textbooks in this field will be compared. The book will likely be purchased by medical libraries, medical bookstores, and scientists and clinicians interested in bone biology.

Bart L. Clarke

The first 53 chapters cover the cells themselves<-->the osteoblast, the osteoclast, and the osteocyte<-->and also covers the biochemistry of collagenous and noncollagenous bone proteins. A second section includes 17 chapters specifically devoted to basic mechanisms of a variety of bone diseases. In the third section, 12 chapters address the advances that have been made in elucidating how old and new drugs act to improve abnormalities in bone metabolism. The 15 chapters in the last section recognize the revolution in investigative methodologies and describe the clinical relevance of bone densitometry and bone biopsies. Annotation c. by Book News, Inc., Portland, Or.

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