Solubility and Solubilization in Aqueous Media

by Samuel H. Yalkowsky

Overview

This book aims to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium. The book begins with the factors which govern solubility in general and then looks at aqueous solubility in particular, including the properties of liquid mixtures and the thermodynamics of solutions formed from mixing two components. The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, cosolvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques.

Product Details

ISBN-13:	9780841235762
Publisher:	American Chemical Society
Publication date:	11/28/1999
Series:	American Chemical Society Publication Series
Pages:	480
Product dimensions:	9.30(w) x 6.30(h) x 0.90(d)

About the Author

University of Arizona

Table of Contents

1. Mixing and Properties of Mixtures
2. Characterization of Solutions
3. Solubility and Partial Miscibility
4. Physical Modification of the Solute
5. Solubilization by pH Control
6. Solubilization by Cosolvents
7. Solubilization by Surfactants
8. Solubilization by Complexation
9. Effect of Cosolutes on Solubility
10. Overview and Strategy for Solubilization
Index

Editorial Reviews

"Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."—SciTech Book News

From the Publisher

Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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