Stem Cells and Cancer

by Sadhan Majumder

Overview

Cancer is a major cause of human morbidity and mortality worldwide. Despite decades of basic and clinical research, the outcome for many cancer patients is still dismal. Although the existence of "stem-like" cells in cancer was hypothesized more than 150 years ago, recent discoveries have the potential to revolutionize cancer therapy. In particular, there is now evidence that many cancers contain self-renewing, drug-and radiation-resistant cells (cancer stem cells or cancer-initiating cells) and it is these cells that are the root cause for cancer initiation, relapse and metastasis. In a single volume, Stem Cells and Cancer offers up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies across all major types of cancer. It provides timely, cutting-edge information about cancer stem cells from the perspectives of both the basic and clinical sciences.

Product Details

ISBN-13:	9781489982872
Publisher:	Springer New York
Publication date:	12/28/2014
Edition description:	2009
Pages:	296
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Stem Cells and Cancer: An Introduction Stewart Sell 1

Molecular Regulation of the State of Embryonic Stem Cells Yuko Fujiwara Stuart H. Orkin 33

MicroRNAs in Stem Cells and Cancer Stem Cells Sanjay K. Singh Mohamedi N. Kagalwala Sadhan Majumder 61

Cancer Stem Cells and Metastasis: Emerging Themes and Therapeutic Implications Leah Owens Benjamin Tiede Yibin Kang 91

Stem Cells in Leukemia and Other Hematological Malignancies Mhairi Copland Alison M. Michie Tessa L. Holyoake 111

Prostate Cancer Stem Cells Elaine M. Hurt George J. Klarmann Brian T. Kawasaki Nima Sharifi William L. Farrar 137

Breast Cancer Stem Cells Bert Gold Michael Dean 167

Stem Cells and Lung Cancer Adam Yagui-Beltrán Biao He David M. Jablons 193

Cancer Stem Cells in Colorectal Cancer Louis Vermeulen Jan Paul Medema James C.H. Hardwick Gijs R. van denBrink 223

Cancer Stem Cells and Skin Cancer Caterina A. M. La Porta 251

Lineage Relationships Connecting Germinal Regions to Brain Tumors Nader Sanai Arturo Alvarez-Buylla 269

Index 287