Systems Biology

by Isidore Rigoutsos (Editor), Gregory Stephanopoulos (Editor)

Overview

The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.

Product Details

ISBN-13:	9780190293758
Publisher:	Oxford University Press
Publication date:	09/14/2006
Series:	Series in Systems Biology
Sold by:	Barnes & Noble
Format:	eBook
File size:	36 MB
Note:	This product may take a few minutes to download.

About the Author

Bioinformatics Group, IBM TJ Watson Researcher Center

MIT

Table of Contents

Contributors     xi
Systems Biology: A Perspective     xiii
Prebiotic Chemistry on the Primitive Earth   Stanley L. Miller   H. James Cleaves     3
Prebiotic Evolution and the Origin of Life: Is a System-Level Understanding Feasible?   Antonio Lazcano     57
Shotgun Fragment Assembly   Granger Sutton   Ian Dew     79
Gene Finding   John Besemer   Mark Borodovsky     118
Local Sequence Similarities   Temple F. Smith     154
Complete Prokaryotic Genomes: Reading and Comprehension   Michael Y. Galperin   Eugene V. Koonin     166
Protein Structure Prediction   Jeffrey Skolnick   Yang Zhang     187
DNA-Protein Interactions   Gary D. Stormo     219
Some Computational Problems Associated with Horizontal Gene Transfer   Michael Syvanen     248
Noncoding RNA and RNA Regulatory Networks in the Systems Biology of Animals   John S. Mattick     269
Index     303