Virulence Mechanisms of Bacterial Pathogens / Edition 4

by Kim A. Brogden

Overview

Bacterial diseases remain a critical issue in public health despite the advent of antibiotics, and the problem presents a rich field for genetic and molecular biology applications. The fourth edition of Virulence Mechanisms of Bacterial Pathogens presents entirely new material on this issue in a ground-breaking overview of the latest knowledge. Internationally recognized authorities explain the wide variety of mechanisms used by bacterial pathogens to cause disease, and then summarize proven strategies for overcoming bacterial virulence mechanisms.

Product Details

ISBN-13:	2901555814693
Publisher:	ASM Press
Publication date:	08/28/2007
Edition description:	REV
Pages:	378
Product dimensions:	6.50(w) x 1.50(h) x 9.50(d)

Table of Contents

Table of Contents

Organizing Committee

Contributors

Preface

Acknowledgments

I. Bacterial Invasion, Colonization, and Survival

Section Editors: James A. Roth and Thad B. Stanton

1. Bacterial Adherence, Colonization, and Invasion of Mucosal Surfaces, John H. Brumell and B. Brett Finlay
2. Bacterial Evasion of Host-Derived Antimicrobial Peptides on Mucosal Surfaces, Kim Alan Brogden
3. Consequences of Bacterial Invasion into Nonprofessional Phagocytic Cells, Jeffrey B. Lyczak and Gerald B. Pier
4. Ecological Aspects of Host Colonization: Coaggregation, Osmoadaptation, and Acid Tolerance or Resistance, Thaddeus B. Stanton
5. Relationships between Community Behavior and Pathogenesis in Pseudomonas aeruginosa, Matthew R. Parsek and E.P. Greenberg
6. Antibiotic Resistance and Survival in the Host, Emma L.A. Macfarlane and Robert E.W. Hancock
II. Bacterial Evasion of Host Defense Mechanisms

Section Editor: Carole A. Bolin

7. What Is the Very Model of a Modern Macrophage Pathogen? David G. Russell
8. Bacterial Resistance to Antibody-Dependent Defenses, Lynette B. Corbeil
9. Mechanisms of Resistance to NO-Related Antibacterial Activity, Andres Vazquez-Torres and Ferric C. Fang
10. DNA Repair and Mutators: Effects on Antigenic Variation and Virulence of Bacterial Pathogens, Thomas A. Cebula and J. Eugene LeClerc
III. Bacterial Effects on Host Cell Function

Section Editor: Michael J. Wannemuehler

11. Bacterial Toxins in Disease Production, Joseph T. Barbieri and Kristin J. Pederson
12. Exploitation of Mammalian Host Cell Function by Shigella spp., Larean D. Brandon and Maricia B. Goldberg
13. Bacterial Induction of Cytokine Secretion in Pathogenesis of Airway Inflammation, Alice Prince
14. The Type III Secretion Pathway: Dictating the Outcome of Bacterial-Host Interactions, Raymond Schuch and Anthony T. Maurelli
IV. Identification, Regulation, and Transfer of Virulence Genes

Section Editor: F. Chris Minion

15. Impact of Horizontal Gene Transfer on Evolution of Salmonella Pathogenesis, Robert A. Kingsley, Renee M. Tsolis, Stacy M. Townsend, Tracy L. Norris, Thomas A. Ficht, L. Garry Adams, and Andreas J. Baumler
16. Regulation of Virulence Gene Expression In Vivo, James M. Slauch
17. Identification of Virulence Genes in Silico: Infectious Disease Genomics, George M. Weinstock, Steven J. Norris, Erica J. Sodergren, and David Smajs
V. Concluding Perspective

Section Editor: Kim A. Brogden

18. State and Future of Studies on Bacterial Pathogenicity: Impact of New Methods of Studying Bacterial Behavior In Vivo, H. Smith

Editorial Reviews

Overviews current knowledge of mechanisms used by bacterial pathogens in establishing infection, producing disease, and persisting in the host. Reviews bacterial invasion, colonization, and survival, and examines bacterial evasion of host defense mechanisms and bacterial effects on host cell function. Discusses identification, regulation, and transfer of virulence genes, and presents an examination of new methods for studying virulence mechanisms in the complex environment. Overall emphasis is on understanding the mechanisms of host-pathogen interactions rather than on specific research approaches. Brogden is affiliated with the US Department of Agriculture. Material originated at a September 1999 conference. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Rebecca T. Horvat, PhD, D (ABMM)(University of Kansas Medical Center)
Description: The increase in technology has allowed researchers the ability to evaluate pathogenicity of bacteria using newer methods with the hope that this information will lead to new diagnostic tests and drugs to prevent and treat these infectious diseases. This book is a compilation of chapters on topics in bacterial pathogenicity.
Purpose: The editor states that the purpose is to provide a "source of information on the virulence mechanisms of bacterial pathogens." Due to the rapid advances that have occurred since the last edition, this edition is necessary to add the current information needed to move the scientific research ahead.
Audience: This is an appropriate reference for researchers in bacterial pathogenicity as well as a textbook for graduate students in this field. The authors are all published experts in the field of bacterial pathogenicity.
Features: More than 35 authors write the 22 chapters. These chapters review research on at least eight different bacterial pathogens as well as the effect of normal bacterial flora on disease progression. A unique chapter on the commensal bacteria and the effect of this bacterial population on disease shows evidence that the products of bacterial metabolism have a great impact on other normal bacterial flora. It is interesting that the diets of the mammalian host in which bacteria are found in large numbers in the gastrointestinal tract affect this metabolism. These bacterial by-products then affect the host cells as well as the neighboring bacterial cells. It is an interesting thought that normal bacterial flora may be a key to preventing disease. Other chapters provide up-to-date information on mechanisms of pathogenicity as well as host responses.
Assessment: This would be a good textbook for a graduate course to study the various mechanisms by which bacteria cause disease. This is a solid new review of various virulence mechanisms used by bacteria.

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