Chiral Separations by Chromatography / Edition 1

by Satinder Ahuja

Overview

The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.

Product Details

ISBN-13:	9780841236318
Publisher:	American Chemical Society
Publication date:	04/28/2000
Series:	American Chemical Society Publication Series
Edition description:	New Edition
Pages:	256
Product dimensions:	6.10(w) x 9.30(h) x 0.70(d)

Table of Contents

1. An Overview
2. Perspectives on Evaluation of Steroisomers as Drug Candidates
3. Review of Stereochemistry
4. Separation Methods
5. Detection Methods
6. Desirable Features of Chiral Stationary Phases
7. Understanding Chiral Chromatography
8. Method Development
9. Preparative Separations
10. Method Selection and Selected Applications
Appendix
Index

Editorial Reviews

"Focuses on developing or selecting suitable chromatographic methods for chiral separations. Provides information on stereochemistry and separation and detection methods such as TLC, GLC, HPLC, and CE, and explores the importance of preparative separations. Illustrates the importance of investigating the stereoisomeric composition of chemical compounds of biological significance, and discusses regulations and requirements as they apply to the development of pharmaceutical compounds. The author is a consultant with many years of experience in research and development of new drugs."—SciTech Book News

From the Publisher