Molecular Pathology of Gastroenterological Cancer: Application to Clinical Practice

by Eiichi Tahara

Overview

The past 20 years have seen remarkable progress in the research, diagnosis, and therapy of gastroenterological cancer. It has been shown that the development and progression of gastric and colon cancers require multiple alternations affecting DNA mismatch repair genes, oncogenes, and tumor-suppressor genes. Pathogenetic research has also demonstrated that the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, providing powerful new tools for early detection. This volume brings together the most recent information on carcinogenesis, biology, molecular genetics, pathology, and molecular diagnosis of gastroenterological cancer, with contributions by renowned researchers from Japan and other parts of the world. Among the topics are experimental stomach carcinogenesis, molecular bases of human stomach carcinogenesis, critical determinants of human colon cancer metastasis, and telomere and telomerase in gastrointestinal cancer. Molecular Pathology of Gastroenterological Cancer is a vital source for oncologists, gastroenterologists, pathologists, epidemiologists, surgeons, and other clinicians.

Product Details

ISBN-13:	9784431659174
Publisher:	Springer Japan
Publication date:	10/03/2013
Edition description:	Softcover reprint of the original 1st ed. 1997
Pages:	267
Product dimensions:	8.27(w) x 10.98(h) x 0.02(d)

Table of Contents

Experimental Stomach Carcinogenesis.- Multistep Carcinogenesis of Esophageal Carcinoma.- Oxidative Damage During the Gastric Precancerous Process.- Multiple Genetic Alterations and Abnormal Growth Factor Network in Human Esophageal Carcinomas.- Genetic Alterations in the Precursors of Gastric Cancer.- Molecular Bases of Human Stomach Carcinogenesis.- Galectins in Gastric and Colorectal Cancers: Implications for Tumor Progression and Metastasis.- Stomach Cancer and Apoptosis: A Review.- Pathogenesis of Serrated Adenoma of the Colorectum: Implication for Malignant Progression.- Carcinoma Cells at Deeply Infiltrated Sites: Role in Development of Metastases in Patients with Advanced Colorectal Adenocarcinomas.- Glycoprotein Hishemistry and the Histogenesis of Colorectal Cancer.- Critical Determinants of Human Colon Cancer Metastasis.- Abnormal CD44 Gene Expression in Neoplasia: Biological and Clinical Implications.- Molecular Diagnosis of Gastrointestinal Cancer.- Interactive Effects of p53 Tumor Suppressor Gene and Hepatitis B Virus in Hepaellular Carcinogenesis.- Molecular Genetics of Hepaellular Carcinoma.- Telomeres and Telomerase in Gastrointestinal Cancers.- Contributor Index.