Foreword
Preface
Editors
Contributors
Introduction; Akira Tsuda and Peter Gehr
Section I: Gas Phase
Deposition; Akira Tsuda and Frank S. Henry
Section II: Airway/Alveolar Surface
Interaction with the Lung Surface; Peter Gehr and Akira Tsuda
Role of the Biomolecule Corona in Nanoparticle Fate and Behavior; Iseult Lynch
Interaction with Alveolar Lining Fluid; Vincent Castranova, Dale W. Porter, and Robert R. Mercer
Interaction with Lung Macrophages; Barry Weinberger, Patrick J. Sinko, Jeffrey D. Laskin, and Debra L. Laskin
Section III: Crossing Epithelial Cells
Interactions with Alveolar Epithelium; Farnoosh Fazlollahi, Yong Ho Kim, Arnold Sipos, Zea Borok, Kwang-Jin Kim, and Edward D. Crandall
Mechanistic Aspects of Cellular Uptake; Lennart Treuel, Xiue Jiang, and Gerd Ulrich Nienhaus
Cellular Uptake and Intracellular Trafficking; Barbara Rothen-Rutishauser, Dagmar A. Kuhn, Dimitri Vanhecke, Fabian Herzog, Alke Petri-Fink, and Martin J.D. Clift
Section IV: Translocation
Translocation across the Air–Blood Tissue Barrier; Fabian Blank, Christophe von Garnier, Peter Gehr, and Barbara Rothen-Rutishauser
The Pulmonary Lymphatic System; Akira Tsuda
Translocation and Accumulation in the Body; Wolfgang G. Kreyling
Section V: Drug Delivery to the Respiratory Tract
Practical Considerations for Drug Delivery to the Respiratory Tract; John S. Patton
Drug and Gene Delivery in the Lungs; Satoshi Uchida, Keiji Itaka, and Kazunori Kataoka
Bio-Nanocapsules: Novel Drug Delivery; Shun’ichi Kuroda
Section VI: Special Issues
Physicochemical, Colloidal, and Transport Properties; Heinrich Hofmann, Lionel Maurizi, Marie-Gabrielle Beuzelin, Usawadee Sakulkhu, and Vianney Bernau
Dosimetry for In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore; Joel M. Cohen and Philip Demokritou
Potential for Nose-to-Brain Delivery of Drugs; Lisbeth Illum
The Developing Lungs; Akira Tsuda and Frank S. Henry
Nanotoxicology; Dominique Balharry, Eva Gubbins, Helinor Johnston, Ali Kermanizadeh, and Vicki Stone
Summary; Peter Gehr and Akira Tsuda
Index